In Plesk v12 or newer, mail can be disabled on a per-domain basis via the Plesk interface.  Go to Mail tab -> Change Settings


For Plesk 11.5, mail service can be disabled for an entire subscription via Mail tab -> Change Settings -> uncheck "Activate mail service on domain", or for an individual domain via command line:


Linux (CentOS):

/usr/local/psa/bin/domain -u -mail_service false


"%plesk_bin%\mailmng.exe" --turn-off-domain
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