In order to set ASP.NET permissions you will need to use the Plesk IIS WP User.

  1.  Login to your Plesk Control Panel
  2. Click on domains and then the domain name that you wish to set permissions for.
  3. Click on file manager.
  4. Browse to the file or folder you wish to set permissions on.
  5. Click on the lock icon on the far right.
  6. Click on the Plesk IIS WP User account.
  7. On the right set the permissions that you need
  8. Click OK.
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